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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IQGAP1 All Species: 10.61
Human Site: S352 Identified Species: 38.89
UniProt: P46940 Number Species: 6
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46940 NP_003861.1 1657 189252 S352 W Y L K Q L L S D K Q Q K R Q
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_536199 1657 189148 S352 W Y L K Q L L S D R Q H K R Q
Cat Felis silvestris
Mouse Mus musculus Q9JKF1 1657 188738 S352 W Y M K Q L Q S D L Q Q K R Q
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509899 540 60910
Chicken Gallus gallus
Frog Xenopus laevis NP_001082590 1618 184741 A343 G V D A G N N A A Q K C Q R K
Zebra Danio Brachydanio rerio NP_001121812 1680 191619 S362 F Y L E H F T S Y R Q H K D A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001203784 771 87814
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 97 N.A. 95.9 N.A. N.A. 28.2 N.A. 80.5 62 N.A. N.A. N.A. N.A. 27.9
Protein Similarity: 100 N.A. N.A. 98.5 N.A. 98 N.A. N.A. 30.8 N.A. 89.1 77.9 N.A. N.A. N.A. N.A. 37.2
P-Site Identity: 100 N.A. N.A. 86.6 N.A. 80 N.A. N.A. 0 N.A. 6.6 33.3 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 N.A. N.A. 93.3 N.A. 86.6 N.A. N.A. 0 N.A. 40 53.3 N.A. N.A. N.A. N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 15 0 0 0 15 15 0 0 0 0 0 15 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 15 0 0 0 % C
% Asp: 0 0 15 0 0 0 0 0 43 0 0 0 0 15 0 % D
% Glu: 0 0 0 15 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 15 0 0 0 0 15 0 0 0 0 0 0 0 0 0 % F
% Gly: 15 0 0 0 15 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 15 0 0 0 0 0 0 29 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 43 0 0 0 0 0 15 15 0 58 0 15 % K
% Leu: 0 0 43 0 0 43 29 0 0 15 0 0 0 0 0 % L
% Met: 0 0 15 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 15 15 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 43 0 15 0 0 15 58 29 15 0 43 % Q
% Arg: 0 0 0 0 0 0 0 0 0 29 0 0 0 58 0 % R
% Ser: 0 0 0 0 0 0 0 58 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 15 0 0 0 0 0 0 0 0 % T
% Val: 0 15 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 43 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 58 0 0 0 0 0 0 15 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _